In the retatrutide phase 2 trial, at 12 mg over 48 weeks, every participant on the highest dose lost at least 5%, 93% lost at least 10%, and 83% lost at least 15%, with roughly two-thirds reaching 20% or more
When sulfonylurea is contraindicated or not tolerated, dual treatment with metformin and other antidiabetic medications such as -glucosidase inhibitors, repaglinide, or dipeptidyl peptidase 4 (DPP4) inhibitors may be initiated [4]
Contact your healthcare provider if diarrhea persists beyond 2-4 weeks at a stable dose, if you experience severe or bloody diarrhea, signs of dehydration (dizziness, decreased urination, extreme thirst), severe abdominal pain, or if symptoms significantly interfere with daily activities or medication adherence
Structurally, resmetirom (MGL-3196) is a synthetic, non-iodinated small molecule that selectively targets THR-
While this may not be true for EACH and EVERY person, its still worth considering
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