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or oral compounds inhibiting dipeptidyl peptidase-4 (DPP-4), the enzyme that inactives GLP-1, also called gliptins (Sitagliptin, Vildagliptin, Saxagliptin, Linagliptin, Alogliptin)

In particular, since CB1Rs, the main target for the rewarding effects of cannabis, are expressed on incretin-secreting cells in rodents and may play a role in regulating GLP-1 secretion [58, 59]

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As they are taken long-term to manage a chronic condition (like cholesterol medicine or blood pressure pills), those costs add up