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Proc Natl Acad Sci USA 1999;96:76806.ArticlePubMedPMC 11

Modulation of the gut microbiota and glycometabolism by a probiotic to alleviate amyloid accumulation and cognitive impairments in AD rats

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This creates a vicious cycle: viral inflammation depletes antioxidants, genetic bottlenecks prevent the synthesis of new antioxidants, and the resulting oxidative stress causes the mitochondria to shut down ATP production, leading to the debilitating fatigue that characterizes ME/CFS and Long COVID