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People taking other AMPK-activating drugs such as metformin, thiazolidinediones, or aspirin without prescriber input, because of theoretical overlap

The FDA Adverse Event Reporting System (FAERS), a pharmacovigilance database maintained by the U.S

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Obesity is a major part of the problem, its complications including chronic kidney disease, hypertensive disease, stroke, and liver disease negatively impacting quality but also quantity of life as life expectancy decreases as body mass index (BMI) increases [3]