In AMPLITUDE-O possible dose-dependent effect for the MACE occurrence was observed
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15 : 421427 Levine J, Barak Y, Gonzalves M, Szor H, Elizur A, Kofman O et al
The fusion of cisplatin with GSH, cysteine (L(+)-Cysteine), and other proteins leads to the depletion of antioxidant reserves in the cytoplasm and causes cellular oxidative stress, which is the major mode of action of cisplatin toxicity