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10.1007/978-3-642-00663-0_7 Adverse Drug Reactions

189 Subsequently, tirzepatide has been extensively investigated in the SURPASS program, a comprehensive development initiative targeting T2DM that is inadequately controlled by various glucose-lowering regimens, including lifestyle alone (SURPASS-1), 190 metformin monotherapy (SURPASS-2), 191 metformin with or without sodium-glucose co-transporter 2 inhibitors (SGLT2i) (SURPASS-3), 192 combination therapy including metformin, SGLT2i, and sulfonylureas (SURPASS-4), 193 insulin glargine with or without metformin (SURPASS-5), 88 and insulin lispro with basal insulin (SURPASS-6)

10.1152/japplphysiol.91235.2008 150 VingrenJ

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Hexavalent chromium exposure induces intestinal barrier damage via activation of the NF-kappaB signaling pathway and NLRP3 inflammasome in ducks