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The recent FLOW trial with semaglutide in patients with chronic kidney disease and T2DM, with a composite of major kidney disease events as the primary outcome, showed significant reductions in both cardiovascular mortality (HR 0.71

Front Med

GLP-1R agonists exert their effects by modulating microglial activity and inflammatory cytokine production in the spinal cord

Firstly, the way that the different drug concentration varies over time seems to play a part, for some people at least, in the short term effectiveness of it