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No difference in abundance of tryptophan and kynurenine suggested that there were no alterations in the initial steps of the de novo pathway, despite downregulation of the kynurenine formamidase (AFMID) enzyme (Figure 4 and Supplemental Figure 3)

Wegovy is a GLP-1 receptor agonist licensed for chronic weight management, whilst Topamax is an antiepileptic drug indicated for epilepsy and migraine prophylaxis

Cagrilintide is a newer long-acting amylin analogue

Ratajczak et al

As the body only absorbs the B12 it needs, there is no risk of overdose