This makes dietary and behavioural strategies especially meaningful for individuals with impaired GLP-1 signalling, such as those with insulin resistance, obesity or type 2 diabetes
How Retatrutide Compares With Related Metabolic Categories Retatrutide is often compared with GLP-1 receptor agonists because GLP-1 activity is part of its mechanism
GLP-1 activation also slows gastric emptying, which means food stays in the stomach longer after eating
This piece in 1993 also provided new insights into the biology of exendin, namely that exendin-4 was a full agonist of the human GLP-1 receptor, which Mojsov argues was crucial to convincing Amylin to develop exendin as a drug for diabetes (see below)
What to Eat (and Limit) if You're Taking a GLP-1 and Have Type 2 Diabetes That can be a good thing for your blood sugar level (fewer big meals means fewer blood sugar spikes), but it can also introduce an additional challenge: eating enough nutrients to protect your heart health, muscle mass, and metabolic health
Interestingly, some women with PCOS might actually experience improved menstrual regularity since GLP-1 drugs lower insulin, a major contributor to irregular periods in women with PCOS
