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All procedures for this study were reviewed and approved by the TAMU Institutional Animal Care and Use Committee (IACUC 2018-0299 CA)

There were side effects, of course: belching, bloating, nausea

Lipoxin A4 upregulates the expressions of GPX4, lysophosphatidic acid receptor-3, and estrogen receptor beta in FLSs, decreases the expression of MMP13 and MMP3, improves the pain performance of OA rats, and alleviates the synovial and cartilage lesions of OA rats by inhibiting ferroptosis

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Clinical Status Human RCT | Observational | Animal | In vitro Primarily studied in preclinical senescence and longevity research models, with no large-scale human clinical trials

MGBA, Microbiota-Gut-Brain Axis