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Mechanism of Action, Safety, and Efficacy Semaglutide exerts its effects through both central and peripheral pathways, replicating and enhancing the physiological actions of endogenous GLP-1 [35]

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In STEP 2, all patients had to have type 2 diabetes to be enrolled, so the BMI cut-off for everyone was 27 kg/m 2 (Table 7)

effects accumulate over 4 to 12 weeks

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