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8-hydroxy-2'-deoxyguanosine (8-OHdG), which reflects oxidative DNA damage, shows measurable increases around the same timeframe

The activation of mTORC1 by glutamine and other amino acids is mediated by the Rag GTPase pathway

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Kalai F, et al

FIGURE 6 These observations align with a cross-sectional study in 51 adults with obesity suggesting altered TMAO metabolism in postmenopausal women ( post hoc analysis excluding the three female participants in the Older group, which are of postmenopausal age based on reports by the WHO ( n = 3