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Pratley, MD, medical director of Advent Translational Research Institute and AdventHealth Diabetes Institute in Orlando, Florida

GIP Receptor (GIPR) Agonism Stimulates robust insulin secretion: GIPR activation enhances glucose-dependent insulin release from pancreatic beta cells, especially effective in the postprandial state 2

GLP-1 Side Effects and Safety GLP-1 medications share similar side effects

Strength: 23 short sessions/week (push, pull, legs, core) to preserve lean mass

Key Distinctions How is Retatrutide different from other GLP-1 receptor agonists

Elevated levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) are commonly found in Hashimoto's patients