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Lack of capacity, compliance issues, or inability to self-administer topical eye drops were also considered exclusion criteria

Clinical trials show tirzepatide is safe beyond 2 years of continuous use with appropriate monitoring

Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial

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However, given the results reported in previous studies (2,25,31-33) that used moderate/high doses of vitamin B12, it should be possible to demonstrate the non-inferiority of the oral treatment with this power level