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It was included as a tertiary agent in the 2017 edition of the multi-agency clinical guidelines for the treatment of hypertension (Whelton et al, 2018), but was no longer mentioned in the 2025 AHA/ACC multisociety hypertension guidelines (Jones et al, 2025)

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H., Cheng, X., & Keidar, M

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Free radicals are molecules that contain an uneven number of electrons and can cause oxidative stress, which is linked to many diseases such as cancer, diabetes, heart disease, and more

For example, if you added 4 mL instead of 3 mL to a 15 mg vial, your new concentration is 15 mg / 4 mL = 3.75 mg/mL