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This is an oversimplification of how one-carbon metabolism works

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Philippe Halban, University of Geneva, Switzerland) were maintained in DMEM at 25 mM d-glucose supplemented with 15% FBS, 50 M -mercaptoethanol, and 1% penicillin/streptomycin 22

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However, this traditional view has been challenged by evidence from numerous clinical studies [43, 44]