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These drugs copy the effects of a natural hormone in the body called glucagon-like peptide-1 (GLP-1)

Samples were resuspended in 160 L EPPS buffer (200 mM, pH 8.0) using a probe sonicator (1 1015 pulses, power output 20%) and then digested with LysC (4 L of 0.5 g/L per sample, resuspended in HPLC grade water, Wako-chemicals, Fujifilm #125-05061) for 2 h at 37 C in a shaker incubator

So obesity and diabetes and certain other conditions are also associated with what we call a low-grade inflammation, and that is being accused of being responsible for some of, or a lot of, the problems that we have in metabolic disease, and that's where GLP-1 has this very pronounced effect on this low-grade inflammation and really puts it down

The bar represents 250 m