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TB-500 is the 17-amino acid LKKTET-containing fragment of thymosin beta-4, responsible for actin cytoskeleton regulation, cell migration, and anti-inflammatory signaling

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In vivo , 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice exhibited a marked reduction in tyrosine hydroxylase (TH)-positive neurons and CD31 expression, along with significant decreases in GSH and GPX4 levels

This data suggests that the ELF GSH level of the maintained adaptive response is calibrated to prevent the CS-induced depletion of GSH levels below basal levels

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