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(6) There are analyses indicating that more than half of all arthroplasty patients are obese, with one large retrospective cohort of 8.3 million individuals reporting that 64% of primary total knee arthroplasty (TKA) patients and 49% of primary total hip arthroplasty (THA) patients are obese

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In comparison with subcutaneous adipocytes, adipocytes isolated from visceral fat were characterized by higher rates of catecholamine-induced lipolysis, 54 , 55 increased expression of -1, -2 and -3 adrenergic receptors, 56 , 57 and reduced responsiveness to the cAMP-lowering effects of -adrenergic agonists