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doi: 10.1530/JME-17-0320 284 SolimanM

After an oral glucose load or a meal, this DPP4 inhibition resulted in a 2- to 3-fold increase in circulating levels of active GLP-1 and GIP, decreased glucagon concentrations, and increased glucose-dependent insulin secretion from pancreatic beta cells

Recent clinical trials(Hardan et al., 2012

However, whether pharmacological inhibition of the enzyme could elevate oxyntomodulin levels sufficiently to contribute to the therapeutic effect of DPP-4 inhibitor therapy is not known

They may suggest adjusting your dose or changing the time of day you take your topiramate

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