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While nausea, vomiting, and diarrhea are the most commonly reported gastrointestinal adverse effects with GLP-1-based therapies (occurring in 15-40% of patients depending on the agent and dose), FDA prescribing information for several of these medications does list dyspepsia (indigestion) and, in some cases, gastroesophageal reflux disease (GERD) as reported adverse reactions
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Short-term observations don't always predict long-term results
Testing before supplementing gives you a baseline to work from and lets you confirm, after 46 weeks, whether your levels have actually improved.
