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The observed SCAN hyperconnectivity in PD was successfully replicated in the full samples of the PIPD dataset (two-tailed independent t = 3.5, P 0.05, FDR corrected)

A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology

and basal insulin (insulin glargine) (19)

Animal Toxicology Limitations Some animal experiments did not report obvious toxicity or increased total tumour incidence

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The 2024 Lancet Commission on dementia prevention, intervention, and care updated its model to include 14 modifiable risk factors and estimated that roughly 45% of dementia cases may be delayed or reduced if those risks are addressed across the lifespan