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Foster JD, Pananusorn B, Vaughan RA

For patients with a confirmed deficiency especially one caused by absorption issues a loading schedule of weekly or biweekly injections is often recommended initially, followed by monthly maintenance injections long-term

These changes suggest cryotherapy actively modulates immune signaling rather than simply masking symptoms

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Research has shown it can modulate glutamate activity, the brains primary excitatory neurotransmitter that opposes GABA

It mimics the incretin hormone GLP-1 to enhance glucose-dependent insulin secretion, suppress glucagon, slow gastric emptying, and reduce appetite through central pathways