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doi: 10.1530/eje.1.01923 99 Lakshmana PerumalNSelviJSridharanKSahooJKamalanathanS

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Bypassing first-pass metabolism utilizes lymphatic delivery for direct access to systemic circulation, targeted release for site-specific delivery, and sustained release to reduce metabolic clearance

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Dosing for maintenance in vegetarians (without confirmed deficiency): 250 mcg per day, or 2,500 mcg once weekly