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In the brain, HGF/c-Met signaling promotes: dendritic spine formation and synaptogenesis
Current medicinal chemistry , 19 1, 126-32
The following FDA-approved drugs have been tested in FXS preclinical and clinical studied: acamprosate (for maintenance of alcohol abstinence), lovastatin (for hypercholesterolemia), minocycline (for acne) and metformin (for non-insulin diabetes mellitus)
Stronger mechanistic clarification would require isoform-specific NOS inhibition, direct measurement of NO metabolites, eNOS phosphorylation analysis, rescue experiments, and comparison across endothelial, epithelial, fibroblast, and neuronal model systems
Journal of Applied Physiology, 109(3), 711718
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