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Subcutaneous and intraperitoneal routes give shorter circulating windows, with the compound clearing primarily through proteolytic degradation outside the GI tract rather than through renal or hepatic elimination as a single molecule

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Tissue inhibitor of metalloproteinase-2 protection of matrix metalloproteinase-2 from degradation by plasmin is reversed by divalent cation chelator EDTA and the bisphosphonate alendronate

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