PLoS ONE (2012)
Similarly, in a diabetic neuropathy mouse model, topiramate administration (10 or 30 mg/kg) led to a significant, dose-dependent reduction in spinal cord levels of TNF- and IL-1 (Attia et al., 2023)
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Tonum cites human clinical trial data reporting about a 10.4% average weight loss over six months and notes that most of the loss was fat rather than lean mass
234 MTAP is located in the periphery of the tumor suppressor cyclin-dependent kinase inhibitor 2 A (CDNK2A), and the co-deletion of the two genes occurs in ~15% of cancers and results in a highly aggressive tumor with a poor prognosis
In epileptic seizures, long-term seizures promote excessive ROS production and lead to the occurrence of oxidative stress, which is closely related to the generation of epileptic activities and the death of nerve cells ( FIGURE 2 Regulation of Ferroptosis by Cysteine-Glutathione (Cys-GSH) Redox Axis Previous studies have shown that oxidative stress causes ferroptosis (Shekh-Ahmad et al., 2019)