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Zepbound and similar agents can theoretically increase pancreatic enzyme levels, which raises concern for patients whose pancreas has already been damaged or inflamed

Increased SIRT1 activity leads to the activation of adipose triacylglycerol lipase (ATGL), with subsequent triacylglycerol depletion of WAT [14]

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The percentage of patients who responded to treatment increased from 34% to nearly 39% after one year (Rotaru et al., 2020)

This insight guides whether you benefit most from dual therapy or can achieve goals with GLP-1 monotherapy