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A growing number of providers and researchers argue that BMI alone is an inadequate assessment tool, particularly for patients who carry metabolic risk at lower body weights

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[9] Co-administration with glucocorticoids or adrenocorticotropic hormone may exacerbate fluid retention and oedema

However, some observational studies have linked very high supplemental intakes of B12 with potential health risks, including increased rates of certain cancers or fractures in specific populations