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This approach isolates any adverse effects to the new agent rather than conflating them with tirzepatide's known tolerability profile

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J Biol Chem 266:37393743 Essa MM, Muthaiyah B, Chauhan V, Brown WT, Chauhan A (2009) Increased oxidative damage in lymphoblasts form autism: enhanced free radical generation coupled with reduced antioxidant status

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GRK2 phosphorylates manifold chemokine receptors such as CCR5, CCR2b, CXCR4, and CXCR2, as well as chemotactic receptors for substance P, S1P, and formyl-peptide, which is in charge of leukocyte trafficking to the inflammatory foci, T-cell egression from lymphoid organs, and leukocyte activation and proliferation (33)