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In October 2023, Reuters published an investigation into reports of increased suicidal ideation among people taking Ozempic and similar drugs
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Of note, a sibling of P1 with a molecularly confirmed diagnosis of clEDS experienced a spontaneous large bowel perforation in middle age
It seems that obesity plays an important role in the pathophysiology of migraine as well, with obese women having elevated plasma levels of calcitonin gene-related peptide (CGRP) compared to controls [32, 33]
Retatrutide adds a third mechanism, glucagon receptor activation, and in Phase 3 trials has demonstrated approximately 28% average body weight reduction over 18 months, compared to tirzepatides 22.5% in its own Phase 3 programme [1][2]