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View Study Jorizzo J, et al

They found that high-dose IGF-1 was beneficial to cartilage formation, while low-dose IGF-1 was more conducive to subchondral bone reconstruction [35]

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At the same time, hepcidin levels increase, thereby accelerating the degradation of FPN, closing the iron transport outlet to the blood, and reducing the transport of iron from small intestinal epithelial cells and macrophages to the blood (Yan et al., 2018)