Drugs Today (Barc) (2013) 49(9):53753

Access this article Similar content being viewed by others Abbreviations ADA: Anti-drug antibody AU: Arbitrary units B/T: Percentage of bound (B) relative to total (T) radioactivity DP: Drug product DPP-IV: Dipeptidyl peptidase-IV DS: Drug substance dSLR: Digital single-lens reflex EC 7080 : 7080% maximal effective concentration GLP-1: Glucagon-like peptide-1 GMP: Good Manufacturing Practice HLA: Human leukocyte antigen HMWP: High-molecular-weight protein HPLC: High-performance liquid chromatography ICPOES: Inductively Coupled Plasma Optical Emission Spectroscopy LC-MS: Liquid chromatography-mass spectrometry LEAD: Liraglutide Effect and Action on Diabetes LOQ: Limit of quantification MHC: Major histocompatibility complex MS: Mass spectrometry nAb: Neutralizing antibody NTU: Nephelometric turbidity units PEG: Polyethylene glycol RP-HPLC: Reverse phase high-performance liquid chromatography s.c.: Subcutaneous SEC: Size exclusion chromatography SUSTAIN: Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes ThT: Thioflavin T UPLC: Ultra-performance liquid chromatography USP: United States Pharmacopeia References Lau JL, Dunn MK

Based on Phase 2 trial data (Jastreboff et al., NEJM , 2023), the most commonly reported adverse effects of retatrutide include: Gastrointestinal effects: Nausea, vomiting, diarrhoea, and constipation (most frequent, particularly during dose escalation) Injection site reactions: Redness, bruising, or mild discomfort Decreased appetite: Generally considered a therapeutic effect but can contribute to nutritional deficiency if severe Increased heart rate: Observed with glucagon receptor agonism
GLP-1 medications suppress appetite
For most GLP-1 receptor agonists, the answer depends on your specific medication and personal routine
Do you have a hard time living in the grey zone, thinking things are either all bad or all good