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There is minimal overlap in their weight loss mechanisms, which suggests potential synergy rather than redundancy

DOI: 10.1038/s41574-025-01171-3 [Google Scholar] Li YK, Ma DX, Wang ZM, Hu XF, Li SL, Tian HZ, et al

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In addition, less than 30% of patients remain on treatment for more than a year 6,7,8 , and treatment discontinuation typically results in rapid weight regain 4,9,10 , with the majority of this gain attributed to increases in fat mass 11,12,13