L., Willis, L., Haffner, S
5 Pharmacological effects of GIP, GLP-1 and their mimetics The pharmacological benefits of GIP, GLP-1, and their synthetic mimetics arise from their pleiotropic effects, encompassing at least five key functions: bolstering insulin secretion and survival of pancreatic -cells and modulating glucagon release by the pancreatic -cells in response to glycemic levels, acting on the satiety center in brain, slowing gastric emptying, regulating lipid and glucose metabolism through effects on adipose tissue and liver, and reducing systemic blood pressure
Topiramate primarily helps with weight loss by affecting brain chemicals that regulate appetite, making you feel fuller and reducing cravings
To support drug discovery in this field, Axxam has developed a comprehensive metabolic assay platform
Both compounds share a fatty-acid conjugation strategy that extends plasma half-life via albumin binding, enabling once-weekly application in vivo models
JastreboffAMLe RouxCWStefanskiAAronneLJHalpernBWhartonSet al
