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Morning injection disadvantages include potential nausea interference with breakfast consumption (some patients need small meals first), and less flexibility if work schedules vary

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Nat Rev Mol Cell Biol 13(10):607625 Fernandes MA, Marques RJ, Vicente JA, Santos MS, Monteiro P, Moreno AJ et al (2008) Sildenafil citrate concentrations not affecting oxidative phosphorylation depress H 2 O 2 generation by rat heart mitochondria

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