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Additionally, immune cells such as macrophages and neutrophils produce free radicals to combat pathogens in a process known as the respiratory burst [23]

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Sleep is often disrupted by pain, and many patients have other sleep disorders, such as restless legs syndrome and sleep apnea

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Post-hoc comparisons showed that the Firmicutes phylums relative abundance was significantly higher in WD control mice compared to mice in the vehicle- and 5A-1MQ-treated groups switched from WD to LD (Fig