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To investigate the effects of miR-221 on the biological function of hair follicle keratinocytes (HF-KCs), we performed western blot assays and found that overexpression of miR-221 significantly reduced IGF-1 expression, leading to a subsequent decline in the proliferation ability of HF-KCs

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The penetration question matters because it points to something Dr Loren Pickart - the biochemist who discovered GHK-Cu - understood from the beginning

IL-4 causes a rapid increase in choline import, phosphocholine production, and PC biosynthesis (67)