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GLP-1 receptor agonists have now received FDA approvals for cardiovascular risk reduction, obstructive sleep apnea, and chronic kidney disease, in addition to their original diabetes and obesity indications

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4 Pathophysiological mechanisms linking testicular and penile microenvironments The penile microenvironment, composed of endothelial cells, cavernous smooth muscle cells, penile nerves, and the extracellular matrix, maintains the structural and functional integrity essential for normal erectile function