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There is a theoretical risk of thyroid effects based on animal studies

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Additionally, glutamate can be converted to glycine through a transamination reaction catalyzed by phosphoserine aminotransferase (PSAT1) into phosphoserine (3-PS) and -KG

Moreover, studies in neonatal porcine and adult human IEC lines have indicated that glutamine also promotes growth through augmenting the effects of growth factors, including insulin-like growth factor 1 and epidermal growth factor (108, 111113)

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These effects have been observed in clinical studies and vary per individual