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However, most individuals regain weight after abrupt withdrawal of semaglutide, with approximately two-thirds of the weight lost being regained within one year [1112]

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For some, the dual-agonist mechanism of Mounjaro provides the perfect balance of efficacy and tolerability, while others may find the single-agonist Wegovy 7.2mg dose, introduced on January 12, 2026, more suitable for their specific metabolic architecture

[3] Malaguarnera M, Cauli O