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How Long a Calorie Deficit Is Generally Safe to Maintain A moderate deficit of 500600 kcal per day is considered safe for most healthy adults

In the work described here, the pharmaceutical formulation used to achieve oral delivery, Axcess- comprising a combination of chenodeoxycholate and propyl gallate as absorption enhancers, is one which has already been employed successfully in humans to achieve delivery of insulin in a safe, efficacious and commercially viable manner