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Am J Physiol Endocrinol Metab 2007

In good agreement, the association between an OCTN2 SNP (rs27437), down-regulating the OCTN2 expression and the CRC risk has been identified (Zou et al., 2018)

showed that GSH is required for cancer initiation partially because of the upregulated activation of the thioredoxin (TXN) antioxidant pathway and inhibition of both GSH and TXN pathway activation, synergistically inhibiting tumor growth 26

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