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This study showed that the median time to onset of the overall GLP-1 RA-related AEs was 31 days (IQR = 7145.4 days), which varied among GLP-1 RA regimens

32 An analysis of US claims data from 107 patients with T2D, 56 of whom were already receiving a GLP1RA, who initiated OW semaglutide showed a 1.3%point reduction in HbA 1c in the overall population

Klnemann M, Andrejev S, Blasche S, Mateus A, Phapale P, Devendran S, Vappiani J, Simon B, Scott TA, Kafkia E et al (2021) Bioaccumulation of therapeutic drugs by human gut bacteria

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This effect has not been clearly demonstrated in humans, but the warning remains as a precaution

References 1 ZhengLZengALiuLTianWWangRZhangLet al