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Furthermore, research using models where anthraquinones like emodin (EMO) themselves induce injury has revealed how protective flavonoids such as isoliquiritigenin work by upregulating cellular detoxification and antioxidant defenses via the Nrf2/Keap1 pathway, showcasing the models utility in studying herb-herb interactions or intrinsic toxicity mitigation (Ni et al., 2022)

Upregulation of BDNF mRNA expression in the barrel cortex of adult mice after sensory stimulation

10.1016/j.envint.2014.10.019 Environ