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FIGURE 5 GHK Increases miR-146a-3p Levels Through the PI3K/Akt Pathway and miR-146a-3p Inhibitor Reverses GHK-induced AQP4 Reduction in Astrocytes

Cystic fibrosis is characterized by Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) dysfunction in the airway epithelium, leading to impaired mucociliary clearance and defective innate immune responses which promote chronic bacterial colonization

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PMID 9501919

2021;321:L485l489

NOX family members normally regulate cellular physiological functions, but under abnormal circumstances contribute to the pathogenesis of cell/tissue damage associated with infections and vascular disorders (Panday et al., 2015)