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To compare the effect of 1-MX against control (CON) and the impact of age, young and old rats were evenly divided into 2 groups per age group (n = 8 per group)

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In Japan a study of 46 diabetic patients (7 type 1, 39 type 2) with moderate glycemic control (glycated hemoglobinA1c 9%) found lower diabetic RBC TK activity in 79% of patients and a concomitant decrease in thiamine level in 76% of diabetics

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Acknowledgements The authors wish to acknowledge Humphrey Chukwudi Omeoga, of Thomas BegLey Laboratory, Department of Biological Sciences, State University of New York, at Albany, New York USA for using his licensed accessed BioRender for the diagrams sketching

Typically, Gram-negative bacteria are the most widely existent bacterial populations in the aquatic environments and hence this is of importance to water systems