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Among the GLP-1RAs, exenatide poses the highest risk since the kidneys eliminate it

The most common side effects are gastrointestinalnausea, vomiting, constipation, or diarrheatypically mild and temporary as your body adjusts

A useful benchmark: if you have lost 20 percent or more of starting body weight, if your appetite is well-controlled, and if you are tolerating the current dose without significant GI burden, there is no clinical imperative to escalate further

A., Boyko, E