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191 The hypothesis that cytoplasmic CTSB triggers apoptosis was further supported by findings showing that CTSB promotes caspase1mediated pyroptosis and exacerbates AP via NLRP3 inflammasome activation

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Zinc also affects antioxidant-enzyme activity (e.g., SOD- superoxide dismutase, catalase), 5-reductase (that limits the conversion of testosterone to DHT - dihydrotestosterone), and mTOR expression, all of which are related to the pathology of PCOS

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Thus agents that inhibit the NET uptake mechanism such as tricylic antidepressants (TCAs) such as imipramine, or any other NET inhibitor including cocaine, antagonize responses to indirectly acting sympathomimetics