Clinical, Cosmetic and Investigational Dermatology, 10, 147153
Why is Kennedy so interested in peptides
When applied topically in a properly formulated serum, GHK-Cu penetrates into the living layers of the skin where it activates a cascade of biological responses: Stimulates fibroblasts to produce collagen I, III, and VI the primary structural proteins of the dermis Activates TGF- the growth factor that signals tissue remodeling and regeneration Inhibits MMP enzymes that break down existing collagen and elastin Upregulates antioxidant enzymes including superoxide dismutase and catalase Modulates over 4,000 genes activating those associated with regeneration and suppressing those associated with inflammation and aging Stimulates proteoglycans including decorin, which regulates collagen fiber organization and gives skin its structured appearance Most skincare peptides work on a single pathway signal peptides stimulate collagen, neurotransmitter peptides relax muscles
Researchers should confirm which salt form the COA references when calculating molar doses
Preclinical studies suggest good tolerability, but comprehensive human trials are needed to establish safety profiles
The toxic effect of silver ions relies on the same chemical features as those of the AgNPs